Research Group - Dr. Qing Wang (Mathematics, PI), Dr. Robert Warburton (Chemistry), and Dr. Zhijun Wang (Computer Science), Shepherd University.
Project Mentor - Dr. David Klinke, Department of Chemical Engineering, Department of Microbiology, Immunology, and Cell Biology, West Virginia University.
Please note: Currently all simulation programs are implemented in C#/ASP.Net and only run with required components installed and impulse/experimental data files in right folders. Please use Internet Explorer/Edge.
Cancer Model Parameter Optimizers and Equation Set Solvers
C07V7 - Added textboxes for the last version.
C07V6 - Added IFN Gamma boundary conditions for days 14, 15, and 18. 12/15/2018.
C07V5 - Output bug fix. 7/28/2018.
C07V4 - Simulator for updated model in July 2018. 1. Add parameter i7 for IL impulses. Two CMHCIm init values (0.054, 0.18). Two groups of impulse files/experimental data. Normalized error. Three folders of outputs - Variance #1. Variance #2. Variance Both.
C08V4 - Solver for updated model in July 2018.
C08V3 - Latest model solver from June 2017. See paper.
New model - Modeling the effect of combination therapy involving Alpha4-1BB, 4-1BB, and IL-12. Please refer to the draft for the model and equations. Impulse files should be placed in the "Impulses" folder on the desktop. Examples - IL, Alpha4-1BB, CMHCIm.
4-1BB & IL-12
|Date||Simulator||Solver||New model - see paper draft circulated by emails. Example impulse files - Dox, A. Impulse files should be placed in the "Impulses" folder on the desktop.|
|Date||Simulator||Solver||Changes were made to equations (6)
and (10) based on an email communication.
Version 2 - Fitness function changed to sum of absolute values of (log10(model prediction)-log10(exp data)). Set log10(exp data) = 0 if exp data = 0.
Version 3 - Change #1. IL impulse functions are multiplied by the day-0 impulse, which used to be only 1s. Function f(x)=(a_1*x^2+b_1*x+1)/(a_2*x^2+b_2*x+1) with parameter values a_1=13.6127, a_2=0.313, b_1=0.8606, b_2=-0.6216 are used for IL12 impulses for 10 days. Change #2. When the tumor size (MHCI+ and MHCI-) is less than 1.0e-7, all tumor compartment variables (equations 8-15) become zeros, until MHCI- gets a new impulse (with a new tumor implant).
Version 4 - Solved the small value (less than 1e-20) issue in numerical solutions and the volt issue.
|Date||Simulator||Solver||5 result files in every partition. Solver not changed.|
|Date||Simulator||Solver||Impulse files should be properly named and put in the "Impulses" folder on the desktop. If "TumorExp.txt" is not on the desktop, the built-in one is used.|
Ebola Model Parameter Optimizers and Equation Set Solvers
|Date||Simulator||Simulator||Simulator||Solver||Cumulative version. E ---> Q.|
|20150703||E03 - Guinea||E03 - Liberia||E03 - Sierra Leone||E04|
|Date||Simulator||Simulator||Simulator||Solver||Impluse files should be properly named and put in the "Impulses" folder on the desktop. If "Guinea.txt", "Liberia.txt", or "SierraLeone.txt" is not on the desktop, the built-in one is used.|
|20150626||E01 - Guinea||E01 - Liberia||E01 - Sierra Leone||E02|
Archived Simulators for Cancer/SARS/H1N1 Models.