Cancer and Ebola Research Simulation Programs

 

Research Group - Dr. Qing Wang (Mathematics, PI), Dr. Robert Warburton (Chemistry), and Dr. Zhijun Wang (Computer Science), Shepherd University.

 

Project Mentor - Dr. David Klinke, Department of Chemical Engineering, Department of Microbiology, Immunology, and Cell Biology, West Virginia University.

 

Please note: Currently all simulation programs are implemented in C# and only run in Internet Explorer with proper components installed.


 

Cancer Model Parameter Optimizers and Equation Set Solvers

 

Date Simulator Solver New model - Modeling the effect of combination therapy involving Alpha4-1BB, 4-1BB, and IL-12. Please refer to the draft for the model and equations. Impulse files should be placed in the "Impulses" folder on the desktop. Examples - IL, Alpha4-1BB, CMHCIm.
20161109   C08    C08V2

 

Date Simulator Solver Changes were made to equations (6) and (10) based on an email communication.
Version 2 - Fitness function changed to sum of absolute values of (log10(model prediction)-log10(exp data)). Set log10(exp data) = 0 if exp data = 0.

Version 3 - Change #1. IL impulse functions are multiplied by the day-0 impulse, which used to be only 1s. Function f(x)=(a_1*x^2+b_1*x+1)/(a_2*x^2+b_2*x+1) with parameter values a_1=13.6127, a_2=0.313, b_1=0.8606, b_2=-0.6216 are used for IL12 impulses for 10 days. Change #2. When the tumor size (MHCI+ and MHCI-) is less than 1.0e-7, all tumor compartment variables (equations 8-15) become zeros, until MHCI- gets a new impulse (with a new tumor implant).
20150726 C05 C06
20151015 C05V2  
20151119 C05V3 C06V3

 

Date Simulator Solver 5 result files in every partition. Solver not changed.
20150703 C03  

Date Simulator Solver Impulse files should be properly named and put in the "Impulses" folder on the desktop. If "TumorExp.txt" is not on the desktop, the built-in one is used.
20150629 C01 C02


 

Ebola Model Parameter Optimizers and Equation Set Solvers

 

Date Simulator Simulator Simulator Solver Cumulative version. E ---> Q.
20150703 E03 - Guinea E03 - Liberia E03 - Sierra Leone E04
Date Simulator Simulator Simulator Solver Impluse files should be properly named and put in the "Impulses" folder on the desktop. If "Guinea.txt", "Liberia.txt", or "SierraLeone.txt" is not on the desktop, the built-in one is used.
20150626 E01 - Guinea E01 - Liberia E01 - Sierra Leone E02

 


 

 Archived Simulators for Cancer/SARS/H1N1 Models.