Research Group - Dr. Qing Wang (Mathematics, PI), Dr. Robert Warburton (Chemistry), and Dr. Zhijun Wang (Computer Science), Shepherd University.

Project Mentor - Dr. David Klinke, Department of Chemical Engineering, Department of Microbiology, Immunology, and Cell Biology, West Virginia University.

Please note: Currently all simulation programs are implemented in C# and only run in Internet Explorer with proper components installed.

**Cancer Model Parameter Optimizers and Equation Set
Solvers**

Date |
Simulator |
Solver |
New model - see paper draft circulated by emails. Example impulse files - Dox, A. Impulse files should be placed in the "Impulses" folder on the desktop. |

20171008 | D01, D01V2 |

Date |
Simulator |
Solver |
C08V3
- Latest model solver from June 2017. See paper. New model - Modeling the effect of combination therapy involving Alpha4-1BB, 4-1BB, and IL-12. Please refer to the draft for the model and equations. Impulse files should be placed in the "Impulses" folder on the desktop. Examples - IL, Alpha4-1BB, CMHCIm. |

20170605 (start) |
C08V3 4-1BB & IL-12 |
||

20161109 | C08 C08V2 |

Date |
Simulator |
Solver |
Changes were made to equations (6)
and (10) based on an email communication. Version 2 - Fitness function changed to sum of absolute values of (log10(model prediction)-log10(exp data)). Set log10(exp data) = 0 if exp data = 0. Version 3 - Change #1. IL impulse functions are multiplied by the day-0 impulse, which used to be only 1s. Function f(x)=(a_1*x^2+b_1*x+1)/(a_2*x^2+b_2*x+1) with parameter values a_1=13.6127, a_2=0.313, b_1=0.8606, b_2=-0.6216 are used for IL12 impulses for 10 days. Change #2. When the tumor size (MHCI+ and MHCI-) is less than 1.0e-7, all tumor compartment variables (equations 8-15) become zeros, until MHCI- gets a new impulse (with a new tumor implant). |

20150726 | C05 | C06 | |

20151015 | C05V2 | ||

20151119 |
C05V3 C05V3A Updated 20170629 |
C06V3 Updated 20170603 |

Date |
Simulator |
Solver |
5 result files in every partition. Solver not changed. |

20150703 | C03 |

Date |
Simulator |
Solver |
Impulse files should be properly named and put in the "Impulses" folder on the desktop. If "TumorExp.txt" is not on the desktop, the built-in one is used. |

20150629 | C01 | C02 |

**Ebola Model Parameter Optimizers and Equation Set
Solvers**

Date |
Simulator |
Simulator |
Simulator |
Solver |
Cumulative version. E ---> Q. |

20150703 | E03 - Guinea | E03 - Liberia | E03 - Sierra Leone | E04 |

Date |
Simulator |
Simulator |
Simulator |
Solver |
Impluse files should be properly named and put in the "Impulses" folder on the desktop. If "Guinea.txt", "Liberia.txt", or "SierraLeone.txt" is not on the desktop, the built-in one is used. |

20150626 | E01 - Guinea | E01 - Liberia | E01 - Sierra Leone | E02 |

Archived Simulators for Cancer/SARS/H1N1 Models.